<![CDATA[Vasoplegia]]> https://www.eurekaselect.com RSS Feed for Disease Wise Article | BenthamScience EurekaSelect (+http://eurekaselect.com) Thu, 28 Mar 2024 12:01:35 +0000 <![CDATA[Vasoplegia]]> https://www.eurekaselect.com https://www.eurekaselect.com <![CDATA[Vasopressin and Related Peptides; Potential Value in Diagnosis, Prognosis and Treatment of Clinical Disorders]]>https://www.eurekaselect.comarticle/81175 <![CDATA[Management of the Low Cardiac Output Syndrome Following Surgery for Congenital Heart Disease]]>https://www.eurekaselect.comarticle/71957 <![CDATA[Inhibitors of Nitric Oxide Synthase: What's up and What's Next?]]>https://www.eurekaselect.comarticle/72100 <![CDATA[Vascular Endothelium and Hypovolemic Shock]]>https://www.eurekaselect.comarticle/72209 <![CDATA[Pharmacological manipulation of peripheral vascular resistance in special clinical situations after pediatric cardiac surgery]]>https://www.eurekaselect.comarticle/71082 <![CDATA[Pharmacological Manipulation of Peripheral Vascular Resistance in Single Ventricle Patients (Stages I, II, and III of Palliation)]]>https://www.eurekaselect.comarticle/71081 <![CDATA[The Inflammatory Response in Cardiac Surgery: An Overview of the Pathophysiology and Clinical Implications]]>https://www.eurekaselect.comarticle/67708 <![CDATA[Anesthetic Pharmacology and Perioperative Considerations for Heart Transplantation]]>https://www.eurekaselect.comarticle/59137 <![CDATA[Role of Peroxynitrite in the Cardiovascular Dysfunction of Septic Shock]]>https://www.eurekaselect.comarticle/49267 <![CDATA[Endothelial Dysfunction in Sepsis]]>https://www.eurekaselect.comarticle/49260

Endothelial dysfunction therefore plays a major role in the pathophysiology of septic shock and organ dysfunction, and has been suggested to be a predictor of mortality in sepsis. Thus, early detection of endothelial dysfunction could be of great interest to adapt treatment in initial stage of sepsis. Current therapeutics used in sepsis mostly aim at controlling inflammation, vascular function and coagulation. Fluid administration, vasopressors, vasodilators and recombinant human activated protein C are also part of the treatments with the ultimate goal to exert beneficial effects on organ function and survival.]]> <![CDATA[Mechanisms of Vascular Hyporesponsiveness in Septic Shock]]>https://www.eurekaselect.comarticle/49259

Methods: Source data were obtained from a PubMed search of the medical literature with the following MeSH terms: Muscle, smooth, vascular/physiopathology; hypotension/etiology; shock/physiopathology; vasodilation/physiology; shock/therapy; vasoconstrictor agents.

Results: NO and peroxynitrite are mainly responsible for vasoplegia and vascular hyporeactivity while COX 2 enzyme is responsible for the increase in PGI2, which also contributes to hyporeactivity. Moreover, K+ATP and BKCa channels are over-activated during septic shock and participate in hypotension. Finally, other mechanisms are involved in vascular hyporesponsiveness such as critical illness-related corticosteroid insufficiency, vasopressin depletion, dysfunction and desensitization of adrenoreceptors as well as inactivation of catecholamines by oxidation.

Conclusion: In animal models, several therapeutic approaches, targeted on one particular compound have proven their efficacy in preventing or reversing vascular hyporesponsiveness to catecholamines. Unfortunately, none have been successfully tested in clinical trials. Nevertheless, very high doses of catecholamines (>5 μg/kg/min), hydrocortisone, terlipressin or vasopressin could represent an alternative for the treatment of refractory septic shock.]]> <![CDATA[Vasopressin and Terlipressin in Neonates and Children with Refractory Septic Shock]]>https://www.eurekaselect.comarticle/48498

However, the pharmacology of vasopressin/terlipressin in newborns and children has not been sufficiently investigated and data on potential short and long-term adverse effects are still lacking. Further clinical, pharmacokinetic and pharmacodynamic studies are needed to better define the role of vasopressin and terlipressin in septic shock, as well as to prove their effectiveness and safety in infants and children.]]> <![CDATA[Atrial Fibrillation in Patients Undergoing Surgical Revascularization: An Update on Pharmacologic Prophylaxis]]>https://www.eurekaselect.comarticle/46432 <![CDATA[Cardiovascular Therapeutics Targets on the NO–sGC–cGMP Signaling Pathway: A Critical Overview]]>https://www.eurekaselect.comarticle/44587 <![CDATA[ Hydrogen Sulfide as a New Endogenous Gaseous Transmitter in the Cardiovascular System]]>https://www.eurekaselect.comarticle/357 <![CDATA[ Therapeutic Use of Antioxidants in Sepsis]]>https://www.eurekaselect.comarticle/37274 <![CDATA[ Mitochondrial Dysfunction during Sepsis]]>https://www.eurekaselect.comarticle/31572

Likewise, organ recovery may depend on restoration of normal mitochondrial respiration. Data from animal studies show histological recovery of mitochondria after a septic insult that precedes clinical improvement. Stimulation of mitochondrial biogenesis could offer a new therapeutic approach for patients in multi-organ failure.

This review will cover basic aspects of mitochondrial function, mechanisms of mitochondrial dysfunction in sepsis, and approaches to prevent, mitigate or speed recovery from mitochondrial injury. ]]> <![CDATA[ Methylene Blue and Vasoplegia: Who, When, and How?]]>https://www.eurekaselect.comarticle/27581 <![CDATA[ Physiological Changes in the Critically Ill Patient with Sepsis]]>https://www.eurekaselect.comarticle/20477 <![CDATA[ Cardiovascular Effects of Modulators of Soluble Guanylyl Cyclase Activity]]>https://www.eurekaselect.comarticle/12685 <![CDATA[ Mesoionic Oxatriazoles (MOTA): NO-Donating Characteristics and Pharmacology]]>https://www.eurekaselect.comarticle/9164 <![CDATA[ Subject Index To Volume 7]]>https://www.eurekaselect.comarticle/3476 <![CDATA[ The Guanylyl Cyclase Inhibition by MB as Vasoplegic Circulatory Shock Therapeutical Target]]>https://www.eurekaselect.comarticle/2770 <![CDATA[ Nitric Oxide and Cardiovascular Dysfunction in Sepsis]]>https://www.eurekaselect.comarticle/2125