Abstract
There is an increased need to find non-invasive tools for early diagnosis and follow-up of infections. Nuclear medicine techniques may be used to diagnose, localize and evaluate the severity and the extent of infections before the occurrence of anatomical abnormalities.
This review focuses on different approaches based on radiolabelled cells, peptides and antibodies or [18F]FDG to image infective diseases in agreement with what is being jointly evaluated by the European Association of Nuclear Medicine (EANM).
This is particularly relevant, since the EANM has strated a wide program of collaboration with other European clinical societies to define common diagnostic flow-charts in many of these infective diseases.
It emerges the role of radiolabelled WBC by SPECT/CT for prosthetic joint infections and of FDG by PET/CT for spondylodiscitis. Comparable values of accuracy have been described for WBC and FDG in the diagnosis of vascular fgraft infections, diabetic gfoot, endocarditis and peripheral bone osteomyelitis, with some exceptions.
Keywords: Nuclear medicine, radiopharmaceutical, Infection imaging, hybrid imaging, [18F]FDG, WBC.
Current Pharmaceutical Design
Title:Current Status of Molecular Imaging in Infections
Volume: 24 Issue: 7
Author(s): Martina Sollini*, Chiara Lauri, Roberto Boni, Elena Lazzeri, Paola Anna Erba and Alberto Signore
Affiliation:
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan,Italy
Keywords: Nuclear medicine, radiopharmaceutical, Infection imaging, hybrid imaging, [18F]FDG, WBC.
Abstract: There is an increased need to find non-invasive tools for early diagnosis and follow-up of infections. Nuclear medicine techniques may be used to diagnose, localize and evaluate the severity and the extent of infections before the occurrence of anatomical abnormalities.
This review focuses on different approaches based on radiolabelled cells, peptides and antibodies or [18F]FDG to image infective diseases in agreement with what is being jointly evaluated by the European Association of Nuclear Medicine (EANM).
This is particularly relevant, since the EANM has strated a wide program of collaboration with other European clinical societies to define common diagnostic flow-charts in many of these infective diseases.
It emerges the role of radiolabelled WBC by SPECT/CT for prosthetic joint infections and of FDG by PET/CT for spondylodiscitis. Comparable values of accuracy have been described for WBC and FDG in the diagnosis of vascular fgraft infections, diabetic gfoot, endocarditis and peripheral bone osteomyelitis, with some exceptions.
Export Options
About this article
Cite this article as:
Sollini Martina *, Lauri Chiara , Boni Roberto , Lazzeri Elena , Erba Anna Paola and Signore Alberto, Current Status of Molecular Imaging in Infections, Current Pharmaceutical Design 2018; 24 (7) . https://dx.doi.org/10.2174/1381612824666180110103348
DOI https://dx.doi.org/10.2174/1381612824666180110103348 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Prevalence of Nasal Colonization with Staphylococcus aureus in Patients with Rheumatoid Arthritis
Current Rheumatology Reviews Exploiting Quorum Sensing Inhibition for the Control of Pseudomonas aeruginosa and Acinetobacter baumannii Biofilms
Current Topics in Medicinal Chemistry Biofilms: An Extra Hurdle for Effective Antimicrobial Therapy
Current Pharmaceutical Design Contrast Enhanced Sonography for Diagnosis of (Peri-) Splenic Pathology
Current Medical Imaging Vaccine Therapy for P. acnes-Associated Diseases
Infectious Disorders - Drug Targets LC-MS for Simultaneous Determination of Vancomycin and Teicoplanin in Patient Plasma and its Application to Therapeutic Drug Monitoring
Current Pharmaceutical Analysis Platelet-Derived Chemokines in Atherogenesis: What’s New?
Current Vascular Pharmacology Cardiovascular Diseases in Pregnancy - A Brief Overview
Current Cardiology Reviews Crystallization and Preliminary X-Ray Crystallographic Studies of SMU.134 Protein from Caries Pathogen Streptococcus mutans
Protein & Peptide Letters Cefixime-induced Oromandibular Dystonia in an Adult: A Case Report
Current Drug Safety Pulmonary Complications After Congenital Heart Surgery
Current Respiratory Medicine Reviews Methylene Blue and Vasoplegia: Who, When, and How?
Mini-Reviews in Medicinal Chemistry Nanomaterials for Photohyperthermia: A Review
Current Pharmaceutical Design β-Lactams in the New Millennium. Part-II: Cephems, Oxacephems, Penams and Sulbactam
Mini-Reviews in Medicinal Chemistry Continuous Infusion of Antibiotics in Critically Ill Patients
Current Clinical Pharmacology Prevention of Bacterial Endocarditis
Cardiovascular & Hematological Disorders-Drug Targets Small Molecule Approaches Toward the Non-Microbicidal Modulation of Bacterial Biofilm Growth and Maintenance
Anti-Infective Agents in Medicinal Chemistry Complementary Therapies in Inflammatory Bowel Diseases
Current Drug Targets Vasopressin and Terlipressin in Neonates and Children with Refractory Septic Shock
Current Drug Metabolism Clinical Features and Disease Damage Risk Factors in an Egyptian SLE Cohort: A Multicenter Study
Current Rheumatology Reviews