Abstract
The effect of anticoagulant adjuvant anti-tumor therapy depends on the cancer type and stage and on the type of the used anticoagulant drug. A striking response rate was described in experiments involving human patients with lung cancer. The aim of this study is to review anticoagulant and fibrinolytic drugs as antitumor agents with focus on their clinical use. The first part of the review evaluates the results of clinical studies. The results of early clinical research are promising and observations suggest novel approaches to the experimental therapy of lung cancer. The second part of the review shortly describes the problem of thrombosis in patients with lung cancer (incidence of thromboembolic disease and its pathogenesis). The third part briefly describes the antimetastatic and antitumor attributes of anticoagulants and fibrinolytics.
Keywords: Lung cancer, Anticoagulants, Fibrinolysis, Heparin, LMWH, Thrombosis, Warfarin
Anti-Cancer Agents in Medicinal Chemistry
Title:Anticoagulant and Fibrinolytic Drugs – Possible Agents in Treatment of Lung Cancer?
Volume: 12 Issue: 6
Author(s): Vladimir Bobek
Affiliation:
Keywords: Lung cancer, Anticoagulants, Fibrinolysis, Heparin, LMWH, Thrombosis, Warfarin
Abstract: The effect of anticoagulant adjuvant anti-tumor therapy depends on the cancer type and stage and on the type of the used anticoagulant drug. A striking response rate was described in experiments involving human patients with lung cancer. The aim of this study is to review anticoagulant and fibrinolytic drugs as antitumor agents with focus on their clinical use. The first part of the review evaluates the results of clinical studies. The results of early clinical research are promising and observations suggest novel approaches to the experimental therapy of lung cancer. The second part of the review shortly describes the problem of thrombosis in patients with lung cancer (incidence of thromboembolic disease and its pathogenesis). The third part briefly describes the antimetastatic and antitumor attributes of anticoagulants and fibrinolytics.
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Cite this article as:
Bobek Vladimir, Anticoagulant and Fibrinolytic Drugs – Possible Agents in Treatment of Lung Cancer?, Anti-Cancer Agents in Medicinal Chemistry 2012; 12 (6) . https://dx.doi.org/10.2174/187152012800617687
DOI https://dx.doi.org/10.2174/187152012800617687 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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