Abstract
Pharmacogenomics, applied as an aspect of molecular autopsy, might become an integral part of forensic medicine in the near future. Pharmacogenomics is the study of the relationship between an individuals genetic/genomic information and the disposition/response to medications. As a result, pharmacogenomics may provide a deeper mechanistic insight necessary for forensic pathologists to fully understand/interpret postmortem toxicology results and correctly determine the cause and manner of death. In this paper, the use of pharmacogenomics as a molecular autopsy tool to raise the standards in forensic medicine is discussed, and illustrated with selected cases. In addition, the current limitations and hurdles for using pharmacogenomics in the postmortem forensic setting are also reviewed.
Keywords: Forensic medicine, forensic pathology, forensic toxicology, pharmacogenomics, postmortem toxicology, standards
Current Pharmacogenomics and Personalized Medicine
Title: Forensic Toxicology and Pharmacogenomics: Hype or Hope For Higher Standards in Forensic Medicine?
Volume: 8 Issue: 2
Author(s): Paul J. Jannetto, Nancy C. Bratanow and Agnieszka Rogalska
Affiliation:
Keywords: Forensic medicine, forensic pathology, forensic toxicology, pharmacogenomics, postmortem toxicology, standards
Abstract: Pharmacogenomics, applied as an aspect of molecular autopsy, might become an integral part of forensic medicine in the near future. Pharmacogenomics is the study of the relationship between an individuals genetic/genomic information and the disposition/response to medications. As a result, pharmacogenomics may provide a deeper mechanistic insight necessary for forensic pathologists to fully understand/interpret postmortem toxicology results and correctly determine the cause and manner of death. In this paper, the use of pharmacogenomics as a molecular autopsy tool to raise the standards in forensic medicine is discussed, and illustrated with selected cases. In addition, the current limitations and hurdles for using pharmacogenomics in the postmortem forensic setting are also reviewed.
Export Options
About this article
Cite this article as:
J. Jannetto Paul, C. Bratanow Nancy and Rogalska Agnieszka, Forensic Toxicology and Pharmacogenomics: Hype or Hope For Higher Standards in Forensic Medicine?, Current Pharmacogenomics and Personalized Medicine 2010; 8 (2) . https://dx.doi.org/10.2174/187569210791383947
DOI https://dx.doi.org/10.2174/187569210791383947 |
Print ISSN 1875-6921 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6913 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Aldosterone, From (Patho)Physiology to Treatment in Cardiovascular and Renal Damage
Current Vascular Pharmacology Induced Pluripotent Stem Cells in Regenerative Medicine and Disease Modeling
Current Stem Cell Research & Therapy A Brief History of ‘Lone’ Atrial Fibrillation: From ‘A Peculiar Pulse Irregularity’ to a Modern Public Health Concern
Current Pharmaceutical Design Patient-Specific Induced Pluripotent Stem Cell Models in Mitochondrial Diseases
Current Stem Cell Research & Therapy New Insights into HLA-G and Inflammatory Diseases
Inflammation & Allergy - Drug Targets (Discontinued) The Right Ventricle: Biologic Insights and Response to Disease
Current Cardiology Reviews The First Line of Defense Against Cardiac Hypertrophy
Current Molecular Medicine Animal Modeling of Cancer Pathology and Studying Tumor Response to Therapy
Current Drug Targets N6-methyladenine RNA Modification (m<sup>6</sup>A): An Emerging Regulator of Metabolic Diseases
Current Drug Targets Interatrial Block in the Modern Era
Current Cardiology Reviews Mitochondrial and Nuclear Genes of Mitochondrial Components in Cancer
Current Genomics Advances in Characterization of Human Sirtuin Isoforms: Chemistries, Targets and Therapeutic Applications
Current Medicinal Chemistry Cardiotonic Steroids, Hypertension and Cardiovascular Disease
Current Hypertension Reviews High-output Cardiac Failure: A Forgotten Phenotype in Clinical Practice
Current Cardiology Reviews Innate Immunity and the Heart
Current Pharmaceutical Design Gender Differences in Response to Therapy for Cardiovascular Diseases
Current Pharmacogenomics and Personalized Medicine Endoplasmic Reticulum Stress as a Novel Therapeutic Target in Heart Diseases
Cardiovascular & Hematological Disorders-Drug Targets Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia
Current Neurovascular Research Bicycloheptylamine-Doxorubicin Conjugate: Synthesis and Anticancer Activities in σ2 Receptor-Expressing Cell Lines
Medicinal Chemistry The Chromogranin A-Derived Vasostatins: New Players in the Endocrine Heart
Current Medicinal Chemistry