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Protein & Peptide Letters

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ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Systematic Review Article

The Renin Angiotensin System and Bipolar Disorder: A Systematic Review

Author(s): Izabela Guimarães Barbosa*, Giulia Campos Ferreira, Diomildo Ferreira Andrade Júnior , Cássio Rocha Januário, André Rolim Belisário, Moises Evandro Bauer and Ana Cristina Simões e Silva

Volume 27, Issue 6, 2020

Page: [520 - 528] Pages: 9

DOI: 10.2174/0929866527666200127115059

Price: $65

Abstract

Bipolar Disorder (BD) is a chronic a multifactorial psychiatric illness that affects mood, cognition, and functioning. BD is associated with several psychiatric conditions as well clinical comorbidities, particularly cardiovascular diseases. The neurobiology of BD is complex and multifactorial and several systems have been implicated. Considering that the Renin Angiotensin System (RAS) plays an important role in cardiovascular diseases and that recently evidence has suggested its role in psychiatric disorders, the aim of the present study is to summarize and to discuss recent findings related to the modulation of RAS components in BD. A systematic search of the literature using the electronic databases MEDLINE and LILACS was conducted through March 2019. The search terms were: “Bipolar Disorder”; “Renin Angiotensin System”; “Angiotensin 2”; “Angiotensin receptors”; “Angiotensin 1-7”; “ACE”; “ACE2”; “Mas Receptor”. We included original studies assessing RAS in BD patients. Two hundred twenty-two citations were initially retrieved. Eleven studies were included in our systematic review. In the majority of studies (6 of 8), the ACE insertion/deletion (I/D) polymorphism did not differ between BD patients and controls. BD patients presented higher plasma renin activity in comparison with controls. The studies evaluating the RAS molecules in BD are very scarce and heterogeneous. The literature suggests a potential role of RAS in BD. Further studies are necessary to investigate this relationship.

Keywords: Renin angiotensin system, angiotensin peptides, bipolar disorder, mania, depression, plasma renin activity.

Graphical Abstract
[1]
Rowland, T.A.; Marwaha, S. Epidemiology and risk factors for bipolar disorder. Ther. Adv. Psychopharmacol., 2018, 8(9), 251-269.
[http://dx.doi.org/10.1177/2045125318769235] [PMID: 30181867]
[2]
Merikangas, K.R.; Jin, R.; He, J.P.; Kessler, R.C.; Lee, S.; Sampson, N.A.; Viana, M.C.; Andrade, L.H.; Hu, C.; Karam, E.G.; Ladea, M.; Medina-Mora, M.E.; Ono, Y.; Posada-Villa, J.; Sagar, R.; Wells, J.E.; Zarkov, Z. Prevalence and correlates of bipolar spectrum disorder in the world mental health survey initiative. Arch. Gen. Psychiatry, 2011, 68(3), 241-251.
[http://dx.doi.org/10.1001/archgenpsychiatry.2011.12] [PMID: 21383262]
[3]
Ferrari, A.J.; Stockings, E.; Khoo, J.P.; Erskine, H.E.; Degenhardt, L.; Vos, T.; Whiteford, H.A. The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disord., 2016, 18(5), 440-450.
[http://dx.doi.org/10.1111/bdi.12423] [PMID: 27566286]
[4]
Yatham, L.N.; Kennedy, S.H.; Parikh, S.V.; Schaffer, A.; Bond, D.J.; Frey, B.N.; Sharma, V.; Goldstein, B.I.; Rej, S.; Beaulieu, S.; Alda, M.; MacQueen, G.; Milev, R.V.; Ravindran, A.; O’Donovan, C.; McIntosh, D.; Lam, R.W.; Vazquez, G.; Kapczinski, F.; McIntyre, R.S.; Kozicky, J.; Kanba, S.; Lafer, B.; Suppes, T.; Calabrese, J.R.; Vieta, E.; Malhi, G.; Post, R.M.; Berk, M. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord., 2018, 20(2), 97-170.
[http://dx.doi.org/10.1111/bdi.12609] [PMID: 29536616]
[5]
Judd, L.L.; Akiskal, H.S.; Schettler, P.J.; Coryell, W.; Endicott, J.; Maser, J.D.; Solomon, D.A.; Leon, A.C.; Keller, M.B. A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder. Arch. Gen. Psychiatry, 2003, 60(3), 261-269.
[http://dx.doi.org/10.1001/archpsyc.60.3.261] [PMID: 12622659]
[6]
Osby, U.; Brandt, L.; Correia, N.; Ekbom, A.; Sparén, P. Excess mortality in bipolar and unipolar disorder in Sweden. Arch. Gen. Psychiatry, 2001, 58(9), 844-850.
[http://dx.doi.org/10.1001/archpsyc.58.9.844] [PMID: 11545667]
[7]
Calkin, C.V.; Gardner, D.M.; Ransom, T.; Alda, M. The relationship between bipolar disorder and type 2 diabetes: more than just co-morbid disorders. Ann. Med., 2013, 45(2), 171-181.
[http://dx.doi.org/10.3109/07853890.2012.687835] [PMID: 22621171]
[8]
McElroy, S.L.; Keck, P.E., Jr Obesity in bipolar disorder: an overview. Curr. Psychiatry Rep., 2012, 14(6), 650-658.
[http://dx.doi.org/10.1007/s11920-012-0313-8] [PMID: 22903246]
[9]
Perugi, G.; Quaranta, G.; Belletti, S.; Casalini, F.; Mosti, N.; Toni, C.; Dell’Osso, L. General medical conditions in 347 bipolar disorder patients: clinical correlates of metabolic and autoimmune-allergic diseases. J. Affect. Disord., 2015, 170, 95-103.
[http://dx.doi.org/10.1016/j.jad.2014.08.052] [PMID: 25237732]
[10]
Rosenblat, J.D.; McIntyre, R.S. Bipolar disorder and immune dysfunction: Epidemiological findings, proposed pathophysiology and clinical implications. Brain Sci., 2017, 30(7), 144.
[11]
Barbosa, I.G.; Bauer, M.E.; Machado-Vieira, R.; Teixeira, A.L. Cytokines in bipolar disorder: paving the way for neuroprogression. Neural Plast., 2014, 2014360481
[http://dx.doi.org/10.1155/2014/360481] [PMID: 25313338]
[12]
Teixeira, A.L.; Salem, H.; Frey, B.N.; Barbosa, I.G.; Machado-Vieira, R. Update on bipolar disorder biomarker candidates. Expert Rev. Mol. Diagn., 2016, 16(11), 1209-1220.
[http://dx.doi.org/10.1080/14737159.2016.1248413] [PMID: 27737600]
[13]
Munkholm, K.; Braüner, J.V.; Kessing, L.V.; Vinberg, M. Cytokines in bipolar disorder vs. healthy control subjects: a systematic review and meta-analysis. J. Psychiatr. Res., 2013, 47(9), 1119-1133.
[http://dx.doi.org/10.1016/j.jpsychires.2013.05.018] [PMID: 23768870]
[14]
Peach, M.J. Renin-angiotensin system: biochemistry and mechanisms of action. Physiol. Rev., 1977, 57(2), 313-370.
[http://dx.doi.org/10.1152/physrev.1977.57.2.313] [PMID: 191856]
[15]
Fyhrquist, F.; Saijonmaa, O. Renin-angiotensin system revisited. J. Intern. Med., 2008, 264(3), 224-236.
[http://dx.doi.org/10.1111/j.1365-2796.2008.01981.x] [PMID: 18793332]
[16]
Kazama, K.; Anrather, J.; Zhou, P.; Girouard, H.; Frys, K.; Milner, T.A.; Iadecola, C. Angiotensin II impairs neurovascular coupling in neocortex through NADPH oxidase-derived radicals. Circ. Res., 2004, 95(10), 1019-1026.
[http://dx.doi.org/10.1161/01.RES.0000148637.85595.c5] [PMID: 15499027]
[17]
Phillips, M.I.; de Oliveira, E.M. Brain renin angiotensin in disease. J. Mol. Med. (Berl.), 2008, 86(6), 715-722.
[http://dx.doi.org/10.1007/s00109-008-0331-5] [PMID: 18385968]
[18]
Kalra, J.; Prakash, A.; Kumar, P.; Majeed, A.B.A. Cerebroprotective effects of RAS inhibitors: Beyond their cardio-renal actions. J. Renin Angiotensin Aldosterone Syst., 2015, 16(3), 459-468.
[http://dx.doi.org/10.1177/1470320315583582] [PMID: 25944853]
[19]
Capettini, L.S.; Montecucco, F.; Mach, F.; Stergiopulos, N.; Santos, R.A.; da Silva, R.F. Role of renin-angiotensin system in inflammation, immunity and aging. Curr. Pharm. Des., 2012, 18(7), 963-970.
[http://dx.doi.org/10.2174/138161212799436593] [PMID: 22283774]
[20]
Simões E Silva, A.C.; Flynn, J.T. The renin-angiotensin-aldosterone system in 2011: role in hypertension and chronic kidney disease. Pediatr. Nephrol., 2012, 27(10), 1835-1845.
[http://dx.doi.org/10.1007/s00467-011-2002-y] [PMID: 21947887]
[21]
Rodrigues Prestes, T.R.; Rocha, N.P.; Miranda, A.S.; Teixeira, A.L.; Simoes-E-Silva, A.C. The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: Evidence from basic and clinical research. Curr. Drug Targets, 2017, 18(11), 1301-1313.
[http://dx.doi.org/10.2174/1389450117666160727142401] [PMID: 27469342]
[22]
Donoghue, M.; Hsieh, F.; Baronas, E.; Godbout, K.; Gosselin, M.; Stagliano, N.; Donovan, M.; Woolf, B.; Robison, K.; Jeyaseelan, R.; Breitbart, R.E.; Acton, S. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res., 2000, 87(5), E1-E9.
[http://dx.doi.org/10.1161/01.RES.87.5.e1] [PMID: 10969042]
[23]
Tipnis, S.R.; Hooper, N.M.; Hyde, R.; Karran, E.; Christie, G.; Turner, A.J. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J. Biol. Chem., 2000, 275(43), 33238-33243.
[http://dx.doi.org/10.1074/jbc.M002615200] [PMID: 10924499]
[24]
Schiavone, M.T.; Santos, R.A.; Brosnihan, K.B.; Khosla, M.C.; Ferrario, C.M. Release of vasopressin from the rat hypothalamo-neurohypophysial system by angiotensin-(1-7) heptapeptide. Proc. Natl. Acad. Sci. USA, 1988, 85(11), 4095-4098.
[http://dx.doi.org/10.1073/pnas.85.11.4095] [PMID: 3375255]
[25]
Block, C.H.; Santos, R.A.; Brosnihan, K.B.; Ferrario, C.M. Immunocytochemical localization of angiotensin-(1-7) in the rat forebrain. Peptides, 1988, 9(6), 1395-1401.
[http://dx.doi.org/10.1016/0196-9781(88)90208-2] [PMID: 3247256]
[26]
Santos, R.A.S.; Simoes e Silva, A.C.; Maric, C.; Silva, D.M.R.; Machado, R.P.; de Buhr, I.; Heringer-Walther, S.; Pinheiro, S.V.B.; Lopes, M.T.; Bader, M.; Mendes, E.P.; Lemos, V.S.; Campagnole-Santos, M.J.; Schultheiss, H.P.; Speth, R.; Walther, T. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc. Natl. Acad. Sci. USA, 2003, 100(14), 8258-8263.
[http://dx.doi.org/10.1073/pnas.1432869100] [PMID: 12829792]
[27]
Chandler, J.; McKenzie, J.; Boutron, I.; Welch, V. Cochrane methods. Cochrane. D.B. Syst. Rev, 2015, 10(Suppl. 1), 1-72.
[http://dx.doi.org/10.1002/14651858.CD201501]
[28]
Wells, G.A.; Shea, B.; O’Connell, D.; Peterson, J.; Welch, V.; Losos, M.; Tugwell, P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analysis, 2019. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
[29]
Kucukali, C.I.; Aydin, M.; Ozkok, E.; Bilge, E.; Zengin, A.; Cakir, U.; Kara, I. Angiotensin-converting enzyme polymorphism in schizophrenia, bipolar disorders, and their first-degree relatives. Psychiatr. Genet., 2010, 20(1), 14-19.
[http://dx.doi.org/10.1097/YPG.0b013e3283351194] [PMID: 20010451]
[30]
Heck, A.; Lieb, R.; Ellgas, A.; Pfister, H.; Lucae, S.; Erhardt, A.; Himmerich, H.; Horstmann, S.; Kloiber, S.; Ripke, S.; Müller-Myhsok, B.; Bettecken, T.; Uhr, M.; Holsboer, F.; Ising, M. Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 2009, 150B(1), 104-114.
[http://dx.doi.org/10.1002/ajmg.b.30784] [PMID: 18484085]
[31]
Konuk, N.; Atik, L.; Simsekyilmaz, O.; Dursun, A.; Acikgoz, S. Association of angiotensin converting enzyme gene polymorphism and affective disorders in Turkish patients. Aust. N. Z. J. Psychiatry, 2006, 40(8), 717-718.
[http://dx.doi.org/10.1111/j.1440-1614.2006.01873.x] [PMID: 16866769]
[32]
Mendlewicz, J.; Oswald, P.; Claes, S.; Massat, I.; Souery, D.; Van Broeckhoven, C.; Del-Favero, J. Patient-control association study of substance P-related genes in unipolar and bipolar affective disorders. Int. J. Neuropsychopharmacol., 2005, 8(4), 505-513.
[http://dx.doi.org/10.1017/S1461145705005444] [PMID: 15927090]
[33]
Pauls, J.; Bandelow, B.; Rüther, E.; Kornhuber, J. Polymorphism of the gene of angiotensin converting enzyme: lack of association with mood disorder. J. Neural Transm. (Vienna), 2000, 107(11), 1361-1366.
[http://dx.doi.org/10.1007/s007020070023] [PMID: 11145009]
[34]
Meira-Lima, I.V.; Pereira, A.C.; Mota, G.F.; Krieger, J.E.; Vallada, H. Angiotensinogen and angiotensin converting enzyme gene polymorphisms and the risk of bipolar affective disorder in humans. Neurosci. Lett., 2000, 293(2), 103-106.
[http://dx.doi.org/10.1016/S0304-3940(00)01512-3] [PMID: 11027844]
[35]
Furlong, R.A.; Keramatipour, M.; Ho, L.W.; Rubinsztein, J.S.; Michael, A.; Walsh, C.; Paykel, E.S.; Rubinsztein, D.C. No association of an insertion/deletion polymorphism in the angiotensin I converting enzyme gene with bipolar or unipolar affective disorders. Am. J. Med. Genet., 2000, 96(6), 733-735.
[http://dx.doi.org/10.1002/1096-8628(20001204)96:6<733:AID AJMG7>3.0.CO;2-8] [PMID: 11121171]
[36]
Arinami, T.; Li, L.; Mitsushio, H.; Itokawa, M.; Hamaguchi, H.; Toru, M. An insertion/deletion polymorphism in the angiotensin converting enzyme gene is associated with both brain substance P contents and affective disorders. Biol. Psychiatry, 1996, 40(11), 1122-1127.
[http://dx.doi.org/10.1016/S0006-3223(95)00597-8] [PMID: 8931914]
[37]
Stewart, P.M.; Atherden, S.M.; Stewart, S.E.; Whalley, L.; Edwards, C.R.; Padfield, P.L. Lithium carbonate--a competitive aldosterone antagonist? Br. J. Psychiatry, 1988, 153, 205-207.
[http://dx.doi.org/10.1192/bjp.153.2.205] [PMID: 3151276]
[38]
Altamura, A.C.; Morganti, A.; Smeraldi, E.; Zanchetti, A. lasma renin activity in primary and secondary depression. Arch. Psychiatr. Nervenkr. (1970), 1977, 224(4), 313-318.
[http://dx.doi.org/10.1007/BF00341613] [PMID: 606204]
[39]
Altamura, A.C.; Morganti, A. Plasma renin activity in depressed patients treated with increasing doses of lithium carbonate. Psychopharmacology (Berl.), 1975, 45(2), 171-175.
[http://dx.doi.org/10.1007/BF00429057] [PMID: 1215447]
[40]
Rigat, B.; Hubert, C.; Alhenc-Gelas, F.; Cambien, F.; Corvol, P.; Soubrier, F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest., 1990, 86(4), 1343-1346.
[http://dx.doi.org/10.1172/JCI114844] [PMID: 1976655]
[41]
Zhang, Z.; Xu, G.; Liu, D.; Fan, X.; Zhu, W.; Liu, X. Angiotensin-converting enzyme insertion/deletion polymorphism contributes to ischemic stroke risk: a meta-analysis of 50 case-control studies. PLoS One, 2012, 7(10)e46495
[http://dx.doi.org/10.1371/journal.pone.0046495] [PMID: 23049705]
[42]
Ishimitsu, T.; Tsukada, K.; Ohta, S.; Inada, H.; Minami, J.; Ono, H.; Matsuoka, H. Increased cardiovascular risk in long-term hemodialysis patients carrying deletion allele of ACE gene polymorphism. Am. J. Kidney Dis., 2004, 44(3), 466-475.
[http://dx.doi.org/10.1016/S0272-6386(04)00816-9] [PMID: 15332219]
[43]
Guney, A.I.; Ergec, D.; Kirac, D.; Ozturhan, H.; Caner, M.; Koc, G.; Kaspar, C.; Ulucan, K.; Agirbasli, M. Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease. Genet. Mol. Res., 2013, 12(4), 6895-6906.
[http://dx.doi.org/10.4238/2013.December.19.8] [PMID: 24391037]
[44]
Goldstein, B.I.; Carnethon, M.R.; Matthews, K.A.; McIntyre, R.S.; Miller, G.E.; Raghuveer, G.; Stoney, C.M.; Wasiak, H.; McCrindle, B.W. American Heart Association Atherosclerosis; Hypertension and Obesity in Youth Committee of the Council on Cardiovascular Disease in the Young. Major depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: A scientific statement from the American Heart Association. Circulation, 2015, 132(10), 965-986.
[http://dx.doi.org/10.1161/CIR.0000000000000229] [PMID: 26260736]
[45]
Mistry, S.; Harrison, J.R.; Smith, D.J.; Escott-Price, V.; Zammit, S. The use of polygenic risk scores to identify phenotypes associated with genetic risk of bipolar disorder and depression: A systematic review. J. Affect. Disord., 2018, 234, 148-155.
[http://dx.doi.org/10.1016/j.jad.2018.02.005] [PMID: 29529547]
[46]
Hayes, J.F.; Miles, J.; Walters, K.; King, M.; Osborn, D.P. A systematic review and meta-analysis of premature mortality in bipolar affective disorder. Acta Psychiatr. Scand., 2015, 131(6), 417-425.
[http://dx.doi.org/10.1111/acps.12408] [PMID: 25735195]
[47]
Goldstein, B.I. Bipolar disorder and the vascular system: Mechanisms and new prevention opportunities. Can. J. Cardiol., 2017, 33(12), 1565-1576.
[http://dx.doi.org/10.1016/j.cjca.2017.10.006] [PMID: 29173599]
[48]
Bhandari, S.K.; Batech, M.; Shi, J.; Jacobsen, S.J.; Sim, J.J. Plasma renin activity and risk of cardiovascular and mortality outcomes among individuals with elevated and nonelevated blood pressure. Kidney Res. Clin. Pract., 2016, 35(4), 219-228.
[http://dx.doi.org/10.1016/j.krcp.2016.07.004] [PMID: 27957416]
[49]
Rocha, N.P.; Simoes E Silva, A.C.; Prestes, T.R.R.; Feracin, V.; Machado, C.A.; Ferreira, R.N.; Teixeira, A.L.; de Miranda, A.S. RAS in the Central Nervous System: Potential Role in Neuropsychiatric Disorders. Curr. Med. Chem., 2018, 25(28), 3333-3352.
[http://dx.doi.org/10.2174/0929867325666180226102358] [PMID: 29484978]
[50]
Vian, J.; Pereira, C.; Chavarria, V.; Köhler, C.; Stubbs, B.; Quevedo, J.; Kim, S.W.; Carvalho, A.F.; Berk, M.; Fernandes, B.S. The renin-angiotensin system: a possible new target for depression. BMC Med., 2017, 15(1), 144.
[http://dx.doi.org/10.1186/s12916-017-0916-3] [PMID: 28760142]

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