The Therapeutic Potential of Neural Stem Cells in Cerebral Ischemia

Yukiko      Kasahara; Takayuki      Nakagomi; Akiko      Nakano-Doi; Tomohiro      Matsuyama; Akihiko      Taguchi

Abstract

Stroke is the leading cause of disability in developed countries, and investigations to identify ways to recover lost neurological function continue. The potential of stem cell therapy could be enormous, but current knowledge and techniques remain limited. In this review article, findings related to the therapeutic potential of acceleration of endogenous neurogenesis and neuronal stem cell transplantation are introduced. The therapeutic effects of acceleration of endogenous neurogenesis have been shown to be mild, but they improve neurological function significantly, and clinical trials are ongoing. In contrast, the potential of neural stem cell transplantation has been reported in many basic experiments, but current basic knowledge and techniques are likely to be insufficient to proceed to clinical trials. The possible missing elements for successful neuronal stem cell transplantation in patients with cerebral infarction are discussed.

Keywords: angiogenesis, cell therapy, cerebral infarction, clinical trial, neural stem cells, neurogenesis, stroke, subventricular zone, vascular endothelial growth factor, granulocyte colony-stimulating factor, brain-derived neurotrophic factor, erythropoietin, endothelial stem/progenitor cell, embolic stem cell, induced pluripotent stem cell, CD34-positive cell, bone marrow mononuclear cell, T-lymphocyte, CD4-positive lymphocyte, CD8-positive lymphocyte, mesenchymal cell, inflammation, apoptotic cell death, immune system, therapeutic time window