Abstract
Apoptosis is a tightly regulated physiologic process of programmed cell death that occurs in both normal and pathologic tissues. Numerous in vitro or in vivo studies have indicated that cardiomyocyte death through apoptosis and necrosis is a primary contributor to the progression of anthracycline-induced cardiomyopathy. There are now several pieces of evidence to suggest that activation of intrinsic and extrinsic apoptotic pathways contribute to anthracyclineinduced apoptosis in the heart. Novel strategies were developed to address a wide variety of cardiotoxic mechanisms and apoptotic pathways by which anthracycline influences cardiac structure and function. Anthracycline-induced apoptosis provides a very valid representation of cardiotoxicity in the heart, an argument which has implications for the most appropriate animal models of damaged heart plus diverse pharmacological effects. In this review we describe various aspects of the current understanding of apoptotic cell death triggered by anthracycline. Differences in the sensitivity to anthracycline-induced apoptosis between young and adult hearts are also discussed.
Keywords: Pediatric, cardiomyopathy, anthracycline, Apoptosis, Cytochrome C, Dexrazoxane, Intrinsic, Mitochondria, extrinsic, caspase
Current Pediatric Reviews
Title: Apoptosis in Anthracycline Cardiomyopathy
Volume: 7 Issue: 4
Author(s): Jianjian Shi, Eltyeb Abdelwahid and Lei Wei
Affiliation:
Keywords: Pediatric, cardiomyopathy, anthracycline, Apoptosis, Cytochrome C, Dexrazoxane, Intrinsic, Mitochondria, extrinsic, caspase
Abstract: Apoptosis is a tightly regulated physiologic process of programmed cell death that occurs in both normal and pathologic tissues. Numerous in vitro or in vivo studies have indicated that cardiomyocyte death through apoptosis and necrosis is a primary contributor to the progression of anthracycline-induced cardiomyopathy. There are now several pieces of evidence to suggest that activation of intrinsic and extrinsic apoptotic pathways contribute to anthracyclineinduced apoptosis in the heart. Novel strategies were developed to address a wide variety of cardiotoxic mechanisms and apoptotic pathways by which anthracycline influences cardiac structure and function. Anthracycline-induced apoptosis provides a very valid representation of cardiotoxicity in the heart, an argument which has implications for the most appropriate animal models of damaged heart plus diverse pharmacological effects. In this review we describe various aspects of the current understanding of apoptotic cell death triggered by anthracycline. Differences in the sensitivity to anthracycline-induced apoptosis between young and adult hearts are also discussed.
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Cite this article as:
Shi Jianjian, Abdelwahid Eltyeb and Wei Lei, Apoptosis in Anthracycline Cardiomyopathy, Current Pediatric Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339611796892265
DOI https://dx.doi.org/10.2174/157339611796892265 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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