Abstract
Tobacco smoking remains the second largest preventable cause of mortality and morbidity worldwide. Exposure to tobacco smoke causes coronary disease, atherosclerosis and ischaemic vessel disease. The degree of this risk is proportional to the amount of smoking and it varies from individual to individual because of between-individual differences in genetic background. While the chemical properties of tobacco smoke are relatively well characterized, the mechanisms by which smoking leads to disease and the genetic factors that determine susceptibility to these diseases are not well understood. The purpose of the present review is to describe the interacti0on between DNA variants in some important genes and cardiovascular diseases; and how the exposure to cigarette smoke significantly modifies the association between genetic variants and cardiovascular risk. A great number of gene-enzymes that usually protect against cardiovascular events may be adversely influenced by tobacco smoke and, through this way, exert less effective action.
Keywords: Cigarette smoking, gene-variant(s), cardiovascular disease
Current Pharmaceutical Design
Title: Interactive Effect of Cigarette Smoking and Gene Variants for Predisposing to Cardiovascular Disease
Volume: 16 Issue: 23
Author(s): Chiara Armani, Linda Landini and Aurelio Leone
Affiliation:
Keywords: Cigarette smoking, gene-variant(s), cardiovascular disease
Abstract: Tobacco smoking remains the second largest preventable cause of mortality and morbidity worldwide. Exposure to tobacco smoke causes coronary disease, atherosclerosis and ischaemic vessel disease. The degree of this risk is proportional to the amount of smoking and it varies from individual to individual because of between-individual differences in genetic background. While the chemical properties of tobacco smoke are relatively well characterized, the mechanisms by which smoking leads to disease and the genetic factors that determine susceptibility to these diseases are not well understood. The purpose of the present review is to describe the interacti0on between DNA variants in some important genes and cardiovascular diseases; and how the exposure to cigarette smoke significantly modifies the association between genetic variants and cardiovascular risk. A great number of gene-enzymes that usually protect against cardiovascular events may be adversely influenced by tobacco smoke and, through this way, exert less effective action.
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Cite this article as:
Armani Chiara, Landini Linda and Leone Aurelio, Interactive Effect of Cigarette Smoking and Gene Variants for Predisposing to Cardiovascular Disease, Current Pharmaceutical Design 2010; 16 (23) . https://dx.doi.org/10.2174/138161210792062885
DOI https://dx.doi.org/10.2174/138161210792062885 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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